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Protein basic information

LiverAtlas Protein ID

HuLPr49090

Uniprot ID

ZN467_HUMAN

Uniprot Acc

Q7Z7K2;

Protein name

Zinc finger protein 467

Comment

FUNCTION:Involved in transcriptional regulation. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS and OSM (By similarity).||SUBUNIT:Interacts with STAT3. Enhances STAT3 activity by keeping it in the nucleus (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity).||SIMILARITY:Belongs to the krueppel C2H2-type zinc-finger protein family.||SIMILARITY:Contains 12 C2H2-type zinc fingers.

Subcellular localization

Nucleus(By similarity).

Gene name

zinc finger protein 467

Protein sequence

MRETLEALSSLGFSVGQPEMAPQSEPREGSHNAQEQMSSS REERALGVCSGHEAPTPEEGAHTEQAEAPCRGQACSAQK AQPVGTCPGEEWMIRKVKVEDEDQEAEEEVEWPQHLSLL PSPFPAPDLGHLAAAYKLEPGAPGALSGLALSGWGPMPE KPYGCGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRS FTQRAHMLLHQRSHRGERPFPCSECDKRFSKKAHLTRHL RTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPC TECEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTHKQ HLVRHQRVHQTAGPARPSPDSSASPHSTAPSPTPSFPGP KPFACSDCGLSFGWKKNLATHQCLHRSEGRPFGCDECAL GATVDAPAAKPLASAPGGPGCGPGSDPVVPQRAPSGERS FFCPDCGRGFSHGQHLARHPRVHTGERPFACTQCDRRFG SRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAV HTGSRPHACAVCARSFSSKTNLVRHQAIHTGSRPFSCPQ CGKSFSRKTHLVRHQLIHGEAAHAAPDAALAAPAWSAPPEVAPPPLFF

Database cross reference

RefSeq Protein accession:NP_997219
RefSeq Protein gi:46409310

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;

Ontology annotation

GO-C

GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0003677;F:DNA binding;IEA:UniProtKB-KW. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.