Protein basic information
| LiverAtlas Protein ID |
HuLPr49244 |
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Uniprot ID |
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Uniprot Acc |
Q9H7S9;Q5XG76; |
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Protein name |
Zinc finger protein 703 |
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Comment |
FUNCTION:Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.||SUBUNIT:Interacts with TLE4; increases transcriptional repression (By similarity). Interacts with DCAF7 and PHB2. May interact with HSPD1.||SUBCELLULAR LOCATION:Nucleus. Cytoplasm (By similarity).||TISSUE SPECIFICITY:Expressed in mammary epithelium.||INDUCTION:Up-regulated by 17-beta-estradiol.||DISEASE:Note=Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-m |
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Subcellular localization |
Nucleus.Cytoplasm(By similarity). |
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Gene name |
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Protein sequence
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MSDSPAGSNPRTPESSGSGSGGGGKRPAVPAAVSLLPPAD PLRQANRLPIRVLKMLSAHTGHLLHPEYLQPLSSTPVSP IELDAKKSPLALLAQTCSQIGKPDPPPSSKLNSVAAAAN GLGAEKDPGRSAPGAASAAAALKQLGDSPAEDKSSFKPY SKGSGGGDSRKDSGSSSVSSTSSSSSSSPGDKAGFRVPS AACPPFPPHGAPVSASSSSSSPGGSRGGSPHHSDCKNGG GVGGGELDKKDQEPKPSPEPAAVSRGGGGEPGAHGGAES GASGRKSEPPSALVGAGHVAPVSPYKPGHSVFPLPPSSI GYHGSIVGAYAGYPSQFVPGLDPSKSGLVGGQLSGGLGL PPGKPPSSSPLTGASPPSFLQGLCRDPYCLGGYHGASHL GGSSCSTCSAHDPAGPSLKAGGYPLVYPGHPLQPAALSS SAAQAALPGHPLYTYGFMLQNEPLPHSCNWVAASGPCDK RFATSEELLSHLRTHTALPGAEKLLAAYPGASGLGSAAA AAAAAASCHLHLPPPAAPGSPGSLSLRNPHTLGLSRYHP YGKSHLSTAGGLAVPSLPTAGPYYSPYALYGQRLASASALGYQ |
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Database cross reference |
RefSeq Protein accession:NP_079345
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;ISS:UniProtKB. GO:0005634;C:nucleus;IDA:UniProtKB. |
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GO-F |
GO:0003676;F:nucleic acid binding;IEA:InterPro. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0016566;F:specific transcriptional repressor activity;IMP:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro. |
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GO-P |
GO:0034333;P:adherens junction assembly;ISS:UniProtKB. GO:0060644;P:mammary gland epithelial cell differentiation;IDA:UniProtKB. GO:0034111;P:negative regulation of homotypic cell-cell adhesion;ISS:UniProtKB. GO:0045892;P:negative regulation of transcri |
