Protein basic information
| LiverAtlas Protein ID |
HuLPr49271 |
|
Uniprot ID |
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Uniprot Acc |
Q32MQ0;Q9H899; |
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Protein name |
Protein ZNF750 |
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Comment |
TISSUE SPECIFICITY:Expressed in the skin, prostate, lung, placenta and thymus, and at low level in T-cells. Not expressed in peripheral blood leukocytes, pancreas and brain. Clearly expressed in primary keratinocytes but not in fibroblasts.||DISEASE:Defects in ZNF750 are the cause of Seborrhea-like dermatitis with psoriasiform (SLDP) [MIM:610227]. SLDP is characterized by a chronic fine diffuse scaly erythematous rash on the face, particularly on the chin, nasolabial folds and eyebrows, around earlobes and over the scalp. The rash exacerbate in the winter, with emotional stress and after strenuous physical activity. Hyperkeratosis of skin over the elbows, knees, palms, soles and metacarpophalangeal joints is evident. There is no arthralgia, arthritis or neurological disorders.||CAUTION:Despite its name, it does not contain a canonical C2H2- type zinc-finger. |
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Gene name |
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Protein sequence
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MSLLKERKPKKPHYIPRPPGKPFKYKCFQCPFTCNEKSHL FNHMKYGLCKNSITLVSEQDRVPKCPKSNSLDPKQTNQP DATAKPASSKSVANGLSAFDSKLQHSSAREDIKENLELQ ARGTHRCLGQKPALHRASPCKSPAPEAALGAQPALEGAA RPSAFVPVGEHRLKGPDNAEAPETLALHNPTAKAVSFHT KSAFHTPGYPWKAGSPFLPPEFPHKISSTKGLGAISPYM HPTIPEYPPHFYTEHGLATIYSPYLLAGSSPECDAPLLS VYGTQDPRHFLPHPGPIPKHLAPSPATYDHYRFFQQYPS NLPIPYGFYRPESAFSSYGLRLPPVTGLTRDQSSHLLEE ATLVYPASSPSRLNPSDPNRKHVEFESPIPEAKDSSKAG QRDTEGSKMSPRAGSAATGSPGRPSPTDFMQTSQTCEGL YDLSNKAASSALGRLYPPEQSLTAFRPVKKSTECLPAQA AETTAESPVSLNVVNGDPPAPTGSASLVSEAAPSSPDDS SGMGPLNLSKKSEINLAATHEPTYQGSPQAETASFSELQ DLPLNLSVKDPCNTQAPRPAFPGRPRAAEPAAAVPQKTG TEGSEDGPSHPETKPGSLDGDGAPPTGPGEEAPDACAVD SSEEQKQTAAVALCQLAAYSPRNIRVGDGDAAAPEPACR QDTPTLSSMESQEAQCDLRPKGQKRTSLRDAGKSQQGAK KAKLQDTARVFTLRRRARVS |
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Database cross reference |
RefSeq Protein accession:NP_078978
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005622;C:intracellular;IEA:InterPro. |
|
GO-F |
GO:0008270;F:zinc ion binding;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr49271 |
PHOSPHORYLATION |
357 |
Y |
PhosphoSitePlus |
LTP |
N |
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