HuLPr49393

Uniprot ID

ZNT5_HUMAN

Uniprot Acc

Q8TAD4;Q6UX54;Q7L4M4;Q8TDG3;Q9H9H1;

Protein name

Zinc transporter 5

Comment

FUNCTION:Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.||SUBUNIT:Heterooligomer. Interacts with ZNT6.||SUBCELLULAR LOCATION:Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8TAD4-1; Sequence=Displayed; Name=2; IsoId=Q8TAD4-2; Sequence=VSP 030254, VSP 030255, VSP 030256;||TISSUE SPECIFICITY:Ubiquitously expre

Subcellular localization

Golgi apparatus, trans-Golgi network membrane;Multi-pass membrane protein.

Gene name

solute carrier family 30 (zinc transporter), member 5

Protein sequence

MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTK FLKAVGLFESYDLLKAVHIVQFIFILKLGTAFFMVLFQK PFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGP LRTLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFI IAVICLLLFDNDDLMAKMAEHPEGHHDSALTHMLYTAIA FLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAK RLQALSHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPF ATVIFFVMILDFYVDSICSVKMEVSKCARYGSFPIFISA LLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSA IFFILSANILSSPSKRGQKGTLIGYSPEGTPLYNFMGDA FQHSSQSIPRFIKESLKQILEESDSRQIFYFLCLNLLFT FVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMS RWKATRIFSYGYGRIEILSGFINGLFLIVIAFFVFMESV ARLIDPPELDTHMLTPVSVGGLIVNLIGICAFSHAHSHA HGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMN ANMRGVFLHVLADTLGSIGVIVSTVLIEQFGWFIADPLC SLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELHIAL EKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLE QRIVQQVTGILKDAGVNNLTIQVEKEAYFQHMSGLSTGF HDVLAMTKQMESMKYCKDGTYIM

Database cross reference

RefSeq Protein accession:NP_075053
RefSeq Protein gi:20070323

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0016324;C:apical plasma membrane;IDA:UniProtKB. GO:0005794;C:Golgi apparatus;IDA:BHF-UCL. GO:0005887;C:integral to plasma membrane;TAS:UniProtKB. GO:0005624;C:membrane fraction;NAS:UniProtKB. GO:0030667;C:secretory granule membrane;EXP:Reactome.

GO-F

GO:0008270;F:zinc ion binding;NAS:UniProtKB. GO:0005385;F:zinc ion transmembrane transporter activity;IDA:UniProtKB.

GO-P

GO:0006882;P:cellular zinc ion homeostasis;IDA:UniProtKB. GO:0006824;P:cobalt ion transport;IDA:MGI. GO:0010155;P:regulation of proton transport;NAS:UniProtKB. GO:0010043;P:response to zinc ion;IDA:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr49393

PHOSPHORYLATION

5

Y

PhosphoSitePlus

474169

LTP

HTP

N