Protein basic information
| LiverAtlas Protein ID |
HuLPr49416 |
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Uniprot ID |
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Uniprot Acc |
Q96SZ4;B3KQD3; |
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Protein name |
Zinc finger and SCAN domain-containing protein 10 |
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Comment |
FUNCTION:Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and THOC4 (By similarity).||SUBUNIT:Interacts with POU5F1/OCT4 and SOX2 (By similarity).||SUBCELLULAR LOCATION:Nucleus (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96SZ4-1; Sequence=Displayed; Name=2; IsoId=Q96SZ4-2; Sequence=VSP 039221; Note=No experimental confirmation available;||SIMILARITY:Contains 14 C2H2-type zinc fingers.||SIMILARITY:Contains 1 SCAN box domain. |
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Subcellular localization |
Nucleus(By similarity). |
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Gene name |
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Protein sequence
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MGPRASLSRLRELCGHWLRPALHTKKQILELLVLEQFLSV LPPHLLGRLQGQPLRDGEEVVLLLEGIHREPSHAGPLDF SCNAGKSCPRADVTLEEKGCASQVPSHSPKKELPAEEPS VLGPSDEPPRPQPRAAQPAEPGQWRLPPSSKQPLSPGPQ KTFQALQESSPQGPSPWPEESSRDQELAAVLECLTFEDV PENKAWPAHPLGFGSRTPDKEEFKQEEPKGAAWPTPILA ESQADSPGVPGEPCAQSLGRGAAASGPGEDGSLLGSSEI LEVKVAEGVPEPNPELQFICADCGVSFPQLSRLKAHQLR SHPAGRSFLCLCCGKSFGRSSILKLHMRTHTDERPHACH LCGHRFRQSSHLSKHLLTHSSEPAFLCAECGRGFQRRAS LVQHLLAHAQDQKPPCAPESKAEAPPLTDVLCSHCGQSF QRRSSLKRHLRIHARDKDRRSSEGSGSRRRDSDRRPFVC SDCGKAFRRSEHLVAHRRVHTGERPFSCQACGRSFTQSS QLVSHQRVHTGEKPYACPQCGKRFVRRASLARHLLTHGG PRPHHCTQCGKSFGQTQDLARHQRSHTGEKPCRCSECGE GFSQSAHLARHQRIHTGEKPHACDTCGHRFRNSSNLARH RRSHTGERPYSCQTCGRSFRRNAHLRRHLATHAEPGQEQ AEPPQECVECGKSFSRSCNLLRHLLVHTGARPYSCTQCG RSFSRNSHLLRHLRTHARETLY |
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Database cross reference |
RefSeq Protein accession:NP_116194
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;ISS:UniProtKB. |
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GO-F |
GO:0043565;F:sequence-specific DNA binding;ISS:UniProtKB. GO:0003700;F:sequence-specific DNA binding transcription factor activity;ISS:UniProtKB. GO:0016564;F:transcription repressor activity;ISS:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro. |
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GO-P |
GO:0006355;P:regulation of transcription, DNA-dependent;IEA:UniProtKB-KW. GO:0016032;P:viral reproduction;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr49416 |
PHOSPHORYLATION |
107 |
S |
PhosphoSitePlus |
HTP |
N |
 
|
|
|
HuLPr49416 |
PHOSPHORYLATION |
167 |
S |
PhosphoSitePlus |
HTP |
N |
|
