HuLPr49974

Uniprot ID

PCDP1_HUMAN

Uniprot Acc

Q4G0U5;B4DEK0;B4E2T5;

Protein name

Primary ciliary dyskinesia protein 1

Comment

FUNCTION: Required for ciliary motility (By similarity).||SUBUNIT: Interacts with calmodulin in the presence of calcium (By similarity).||SUBCELLULAR LOCATION: Cell projection, cilium.||ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4G0U5-1; Sequence=Displayed; Name=2; IsoId=Q4G0U5-2; Sequence=VSP 039316; Name=3; IsoId=Q4G0U5-3; Sequence=VSP 039317, VSP 039320, VSP 039321; Name=4; IsoId=Q4G0U5-4; Sequence=VSP 039319, VSP 039318;||TISSUE SPECIFICITY: Expressed in ciliated respiratory epithelial cells and brain ependymal cells (at protein level).||SIMILARITY: Belongs to the PCDP1 family.

Subcellular localization

Cell projection, cilium.

Gene name

primary ciliary dyskinesia protein 1

Protein sequence

MAVVKTPSRGLKNAKEPFNNASPHLLKNLVEEPKKRKEVP NHLLESKVYAKLVNNKVIQARPGIIHFGGYQVEKQHQQI LHLVNVSNEDTRVHILPPQTKYFEINYVRKEHHLVPGLS LTVTVTFSPDEWRYYYDCIRVHCKGDDTLLVPIHAYPVM NSLDFPSFINLSNVLLGESKTYVIPLQCSCPVDFEFYIT LIQSHQAFAIEPTSGIIPANGKMTVTIKFTPFQYGTAQI KMQLWISQFNSQPYECVFTGTCYPNMALPLEEFERLNTL SKKVNVPPEKAMMHINFHRPPAKPKPQKVKEIEYQNLRF PVDLSNPFAVATVLNQEPGKLKIKELREVLDQGTEISKT RQMKEALFEQKVRQDIHEEMENHLKWQVHLGKDPMSFKL KKELTEEWQKACAKYKLDRGDPILDEEFQRLKTEVSHKR VVRNQEEKIKEFHPTFDPLINNTWLSRSRAQKRFQQVAR KVMIQGRLFNMLSAVREMDKESILRKIGQAKQSIAQEAN FFKFFLRRISQDDYTSRFSVSPKEVLPFAFPDCSPPQDS NELAPDGLGLVPIKSSEVQIKQSYSFFNLQVPQLYKIKR YQPFSVHKSSTSYRPQKLARALKQGAEDEVTTITALPKQ DSTTQLSGKTSVLSMKPPEALAMSLDYDPLYVFNPNPGL FAVMHPLTYAETLIDYHLCSHPKYKFTKESRHGSSIPVT QKQFLHHTDIIPGIMHWKSFQSLVLSSLPDPSKMETTKS CDSFNSFMLPIDVPAILDALPEEDRLETVERELCEQNVE VMLTPEMIKVEFPMLNYKDIRKEKEVKDQAQPAEKAGEK LLEEMRNLRGKALNTYLILE

Database cross reference

RefSeq Protein accession:NP_001025167
RefSeq Protein gi:284447256

GO:0005929; C:cilium; IEA:UniProtKB-SubCell.

GO-F

GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.