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Protein basic information

LiverAtlas Protein ID

HuLPr49991

Uniprot ID

Q0D2M2_HUMAN

Uniprot Acc

Q0D2M2;

Protein name

HIST1H2BC protein

Comment

FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).

Gene name

histone cluster 1, H2bc

Protein sequence

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSV YVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEAS RLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSGGTKA VTKYTSSK

Database cross reference

RefSeq Protein accession:NP_003517
RefSeq Protein gi:21166389

Ontology annotation

GO-C

GO:0000786; C:nucleosome; IEA:UniProtKB-KW. GO:0005634; C:nucleus; IEA:UniProtKB-KW.

GO-F

GO:0003677; F:DNA binding; IEA:UniProtKB-KW.

GO-P

GO:0006334; P:nucleosome assembly; IEA:InterPro.