Protein basic information
| LiverAtlas Protein ID |
HuLPr50108 |
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Uniprot ID |
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Uniprot Acc |
Q8IZD6;A8MUR3;Q6UXP5;Q8TAL9;Q9NSH5; |
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Protein name |
Solute carrier family 22 member 15 |
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Comment |
FUNCTION: Probably transports organic cations (By similarity). Appears not to be the agmatine transporter.||SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IZD6-1; Sequence=Displayed; Name=2; IsoId=Q8IZD6-2; Sequence=VSP 034059, VSP 034060;||TISSUE SPECIFICITY: Expressed at highest levels in kidney and brain. Expressed at high levels in skeletal muscle, heart, liver, placenta and white blood cells. Expressed at moderate levels in lung and spleen. Expressed at low levels in thymus, small intestine and colon. Expressed in several intestinal tumor cell lines.||DEVELOPMENTAL STAGE: Expressed at low levels at 20-25 weeks of gestation in fetal brain, lung, liver and kidney.||SIMILARITY: Belongs to the major facilitator superfamily. Organic cation transporter family.||SEQUENCE CAUTION: Sequence=AAH26358.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence |
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Subcellular localization |
Membrane; Multi-pass membrane protein (Potential). |
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Gene name |
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Protein sequence
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MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIA LVGATPSYHWDLAELLPNQSHGNQSAGEDQAFGDWLLTA NGSEIHKHVHFSSSFTSIASEWFLIANRSYKVSAASSFF FSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANG FSPSYEFFAVTRFLVGMMNGGMSLVAFVLLNECVGTAYW ALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQG TVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK LKCTFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMF IWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYP LCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKD TGVFAVVNSHSLSLLGKLTISAAFNIVYIYTSELYPTVI RNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGA TGLTSGLLSLLLPETLNSPLLETFSDLQVYSYRRLGEEA LSLQALDPQQCVDKESSLGSESEEEEEFYDADEETQMIK |
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Database cross reference |
RefSeq Protein accession:NP_060890
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Ontology annotation
| GO-C |
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. |
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GO-F |
GO:0005215; F:transporter activity; IEA:InterPro. |
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GO-P |
GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0055085; P:transmembrane transport; IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr50108 |
PHOSPHORYLATION |
253 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr50108 |
PHOSPHORYLATION |
266 |
Y |
PhosphoSitePlus |
LTP |
N |
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