HuLPr50112

Uniprot ID

SAC31_HUMAN

Uniprot Acc

A6NKF1;A8MX08;Q99773;

Protein name

SAC3 domain-containing protein 1

Comment

FUNCTION: Involved in centrosome duplication and mitotic progression (By similarity).||SUBUNIT: May be part of a SHFM1-containing complex.||SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Localizes on centrosomes in interphase cells and at spindles in mitosis (By similarity).||ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=A6NKF1-1; Sequence=Displayed; Name=2; IsoId=A6NKF1-2; Sequence=VSP 036589; Note=No experimental confirmation available;||SIMILARITY: Belongs to the SAC3 family.||CAUTION: It is uncertain whether Met-1 or Met-47 is the initiator.||SEQUENCE CAUTION: Sequence=AP003068; Type=Erroneous gene model prediction;

Subcellular localization

Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Localizes on centrosomes in interphase cells and at spindles in mitosis (By similarity).

Gene name

SAC3 domain containing 1

Protein sequence

MAGRRAQTGSAPPRPAAPHPRPASRAFPQHCRPRDAERPP SPRSPLMPGCELPVGTCPDMCPAAERAQREREHRLHRLE VVPGCRQDPPRADPQRAVKEYSRPAAGKPRPPPSQLRPP SVLLATVRYLAGEVAESADIARAEVASFVADRLRAVLLD LALQGAGDAEAAVVLEAALATLLTVVARLGPDAARGPAD PVLLQAQVQEGFGSLRRCYARGAGPHPRQPAFQGLFLLY NLGSVEALHEVLQLPAALRACPPLRKALAVDAAFREGNA ARLFRLLQTLPYLPSCAVQCHVGHARREALARFARAFST PKGQTLPLGFMVNLLALDGLREARDLCQAHGLPLDGEER VVFLRGRYVEEGLPPASTCKVLVESKLRGRTLEEVVMAE EEDEGTDRPGSPA

Database cross reference

GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0005819; C:spindle; IEA:UniProtKB-SubCell.

GO-F

GO:0005515; F:protein binding; IPI:UniProtKB.

GO-P

GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr50112

PHOSPHORYLATION

402

S

PhosphoSitePlus

453591

LTP

N