HuLPr50113

Uniprot ID

SC5AC_HUMAN

Uniprot Acc

Q1EHB4;Q86UC7;

Protein name

Sodium-coupled monocarboxylate transporter 2

Comment

FUNCTION: Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).||ENZYME REGULATION: Cotransport of monocarboxylates and nicotinate strongly inhibited by ibuprofen, fenoprofen and ketoprofen.||SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity).||ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named iso

Subcellular localization

Apical cell membrane; Multi-pass membrane protein. Note=Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity).

Gene name

solute carrier family 5 (sodium/glucose cotransporter), member 12

Protein sequence

MEVKNFAVWDYVVFAALFFISSGIGVFFAIKERKKATSRE FLVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGA SFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLR FNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFD LWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGF LTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRR HTFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKL ALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIIS APDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASS INALATVTFEDFVKSCFPHLSDKLSTWISKGLCLLFGVM CTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVF PFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPL PLSTDQCIKSNVTATGPPVLSSRPGIADTWYSISYLYYS AVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFC FWSKKYKTLCWCGVQHDSGTEQENLENGSARKQGAESVL QNGLRRESLVHVPGYDPKDKSYNNMAFETTHF

Database cross reference

RefSeq Protein accession:NP_848593
RefSeq Protein gi:157671931

GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.

GO-F

GO:0015293; F:symporter activity; IEA:UniProtKB-KW.

GO-P

GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.