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Protein basic information

LiverAtlas Protein ID

HuLPr50130

Uniprot ID

SYNE4_HUMAN

Uniprot Acc

Q8N205;A8MRS0;A8MYE3;Q7Z7L3;

Protein name

Nesprin-4

Comment

FUNCTION: Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity).||SUBUNIT: Interacts with KIF5B and KCL1 (By similarity).||SUBCELLULAR LOCATION: Nucleus outer membrane; Single-pass type IV membrane protein (By similarity). Note=The nucleus outer membrane location requires the presence of a SUN domain-containing protein (By similarity).||ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N205-1; Sequence=Displayed; Name=2; IsoId=Q8N205-2; Sequence=VSP 028444;||DOMAIN: The KASH domain, which contains a transmembrane domain, mediates the nuclear envelope targeting and is involved in the binding to SUN1 and SUN2 through recognition of their SUN domains (By similarity).||SIMILARITY: Belongs to the nesprin family.||SIMILARITY: Contains 1 KASH domain.||SEQUENCE CAUTION: Sequence=BAC04222.1; Type=Miscellan

Subcellular localization

Nucleus outer membrane; Single-pass type IV membrane protein (By similarity). Note=The nucleus outer membrane location requires the presence of a SUN domain-containing protein (By similarity).

Gene name

chromosome 19 open reading frame 46

Protein sequence

MALSLPLGPRLGSEPLNHPPGAPREADIVGCTVCPASGEE STSPEQAQTLGQDSLGPPEHFQGGPRGNEPAAHPPRWST PSSYEDPAGGKHCEHPISGLEVLEAEQNSLHLCLLGLGR RLQDLEQGLGHWALAQSGMVQLQALQVDLRGAAERVEAL LAFGEGLAQRSEPRAWAALEQILRALGAYRDSIFRRLWQ LQAQLVSYSLVFEEANTLDQDLEVEGDSDWPGPGGVWGP WAPSSLPTSTELEWDPAGDIGGLGPLGQKTARTLGVPCE LCGQRGPQGRGQGLEEADTSHSRQDMLESGLGHQKRLAR HQRHSLLRKPQDKKRQASPHLQDVRLEGNPGAPDPASRQ PLTFLLILFLLFLLLVGAMFLLPASGGPCCSHARIPRTP YLVLSYVNGLPPV

Database cross reference

RefSeq Protein accession:NP_001034965
RefSeq Protein gi:89886475

Ontology annotation

GO-C

GO:0031309; C:integral to nuclear outer membrane; ISS:UniProtKB.

GO-F

GO:0003779; F:actin binding; IEA:InterPro.

GO-P

GO:0045198; P:establishment of epithelial cell apical/basal polarity; ISS:UniProtKB.