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Protein basic information

LiverAtlas Protein ID

HuLPr50163

Uniprot ID

WDR34_HUMAN

Uniprot Acc

Q96EX3;Q5VXV4;Q9BV46;

Protein name

WD repeat-containing protein 34

Comment

FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa- B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.||SUBUNIT: Interacts (via the WD domains) with MAP3K7 and TAB3. Interacts (via WD domains) with TAB2 (via C-terminus). Interacts (via WD domains) with TRAF6 (via TRAF-type domains).||SUBCELLULAR LOCATION: Cytoplasm.||TISSUE SPECIFICITY: Expressed in several cell lines (at protein level).||SIMILARITY: Contains 5 WD repeats.

Subcellular localization

Cytoplasm.

Gene name

WD repeat domain 34

Protein sequence

MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQD ETLGVASVPSQWRAVQGIRWETKSCQTASIATASASAQA RNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAM VIRELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPA QAQGLHVTSISWNSTGSVVACAYGRLDHGDWSTLKSFVC AWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAG GLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVW LPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFA LVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFIL GTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPH GGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTS LQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSS QKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVK VWQLSTEFTEQGPREAEDLDCLAAEVAA

Database cross reference

RefSeq Protein accession:NP_443076
RefSeq Protein gi:66267730

Ontology annotation

GO-C

GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.