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Protein basic information

LiverAtlas Protein ID

HuLPr50168

Uniprot ID

ZBED6_HUMAN

Uniprot Acc

P86452;

Protein name

Zinc finger BED domain-containing protein 6

Comment

FUNCTION: Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing this consensus binding site (By similarity).||SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus (By similarity).||MISCELLANEOUS: Encoded by an exapted DNA transposon located in an intron of the ZC3H11A gene.||SIMILARITY: Contains 2 BED-type zinc fingers.

Subcellular localization

Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus (By similarity).

Gene name

zinc finger, BED-type containing 6

Protein sequence

MSVCTLSVPVSSLSPGRRCNTFSDSGILGCVPINSNTDEE DVVEEKMVAEGVNKEAKQPAKKKRKKGLRIKGKRRRKKL ILAKKFSKDLGSGRPVADAPALLASNDPEQDEESLFESN IEKQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKS VSRGKPGSHLGTSTLQRHLQARHSPHWTRANKFGVASGE EDFTLDVSLSPSSGSNGSFEYIPTDPLDDNRMGKKHDKS ASDALRAERGRFLIKSNIVKHALIPGTRAKTSAVWNFFY TDPQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQAT HPIHWAVANKDSGAVANGLDEAETERSDLLSDTLHGEKS TGSQDLTAEDLSDSDSDEPMLEVENRSESPIPVAEQGTL MRAQERETTCCGNPVSSHISQAIIQMIVEDMHPYNYFST PAFQRFMQIVAPDYRLPSETYFFTKAVPQLYDCVREKIF LTLENVQSQKIHLTVDIWTHDPSTDYFIVTVHWVSLETA SFLNNGRIPDFRKWAVLCVTGLAKDCLITNILQELNDQI GLWLSPNFLIPSFIVSDNSSNVVHAIKDGGFTHVPCFLH CLNMVIQDFFCEHKSIENMLVAARKTCHHFSHSVKARQI LQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLEHCYS VHHSLGRASGVVLTSLQWTLMTYVCDILKPFEEATQKVS VKTAGLNQVLPLIHHLLLSLQKLREDFQVRGITQALNLV DSLSLKLETDTLLSAMLKSKPCILATLLDPCFKNSLEDF FPQGADLETYKQFLAEEVCNYMESSPEICQIPTSEASCP SVTVGADSFTSSLKEGTSSSGSVDSSAVDNVALGSKSFM FPSAVAVVDEYFKEKYSEFSGGDDPLIYWQRKISIWPAL TQVAIQYLSCPMCSWQSECIFTKNSHFHPKQIMSLDFDN IEQLMFLKMNLKNVNYDYSTLVLSWDPEQNEVVQSSEKEILP

Database cross reference

RefSeq Protein accession:NP_001167579
RefSeq Protein gi:291621630

Ontology annotation

GO-C

GO:0005730; C:nucleolus; ISS:UniProtKB.

GO-F

GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0046983; F:protein dimerization activity; IEA:InterPro. GO:0016564; F:transcription repressor activity; ISS:UniProtKB.

GO-P

GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.