Protein basic information
| LiverAtlas Protein ID |
HuLPr50221 |
|
Uniprot ID |
|
|
Uniprot Acc |
P25025;Q8IUZ1;Q9P2T6;Q9P2T7; |
|
Protein name |
C-X-C chemokine receptor type 2 |
|
Comment |
FUNCTION: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.||SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.||PTM: Phosphorylated upon ligand binding; which is required for desensitization.||SIMILARITY: Belongs to the G-protein coupled receptor 1 family.||WEB RESOURCE: Name=Wikipedia; Note=CXC chemokine receptors entry; URL="http://en.wikipedia.org/wiki/CXC chemokine receptors";||WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il8rb/"; |
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Subcellular localization |
Cell membrane; Multi-pass membrane protein. |
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Gene name |
|
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Protein sequence
|
MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCE PESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVG RSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFL CKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQ KRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPAC YEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTL RTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLAD TLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLI YAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSS SGHTSTTL |
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Database cross reference |
RefSeq Protein accession:NP_001161770
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Ontology annotation
| GO-C |
GO:0009986; C:cell surface; IDA:UniProtKB. GO:0005887; C:integral to plasma membrane; TAS:UniProtKB. GO:0042629; C:mast cell granule; IDA:UniProtKB. |
|
GO-F |
GO:0004918; F:interleukin-8 receptor activity; IDA:UniProtKB. |
|
GO-P |
GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; IDA:UniProtKB. GO:0006968; P:cellular defense response; IDA:UniProtKB. GO:0002407; P:dendritic cell chemotaxis; |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr50221 |
PHOSPHORYLATION |
352 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr50221 |
PHOSPHORYLATION |
353 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr50221 |
PHOSPHORYLATION |
347 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr50221 |
PHOSPHORYLATION |
351 |
S |
Phospho-ELM |
LTP |
N |
|
|
|
HuLPr50221 |
PHOSPHORYLATION |
347 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50221 |
PHOSPHORYLATION |
351 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50221 |
PHOSPHORYLATION |
352 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50221 |
PHOSPHORYLATION |
353 |
S |
PhosphoSitePlus |
LTP |
N |
|
