Protein basic information
| LiverAtlas Protein ID |
HuLPr50231 |
|
Uniprot ID |
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|
Uniprot Acc |
Q7Z434;Q2HWT5;Q3I0Y2;Q5T7I6;Q86VY7;Q9H1H3;Q9H4Y1;Q9H8D3;Q9ULE9; |
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Protein name |
Mitochondrial antiviral-signaling protein |
|
Comment |
FUNCTION: Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.||SUBUNIT: Interacts with DDX58, IFIH1, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, IKBKE, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1 (By similarity). Interacts (via C-terminus) with PCBP2 in a complex containing MAVS, PCBP2 and ITCH. Interacts with CYLD. Interacts with SRC.||INTERAC |
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Subcellular localization |
Mitochondrion outer membrane. |
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Gene name |
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Protein sequence
|
MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQD RLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGC ELVDLADEVASVYQSYQPRTSDRPPDPLEPPSLPAERPG PPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENS EQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQ EQDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTP RASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAE SDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVP ANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPIN STRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAA PTPAGATGGSSAWLDSSSENRGLGSELSKPGVLASQVDS PFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIH VAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPC HRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH |
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Database cross reference |
RefSeq Protein accession:NP_001193420
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Ontology annotation
| GO-C |
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005741; C:mitochondrial outer membrane; IDA:BHF-UCL. |
|
GO-F |
GO:0050700; F:CARD domain binding; IPI:BHF-UCL. GO:0019901; F:protein kinase binding; IPI:BHF-UCL. GO:0004871; F:signal transducer activity; IMP:UniProtKB. |
|
GO-P |
GO:0002218; P:activation of innate immune response; IMP:BHF-UCL. GO:0071360; P:cellular response to exogenous dsRNA; IMP:BHF-UCL. GO:0042742; P:defense response to bacterium; IMP:UniProtKB. GO:0045087; P:innate immune response; IMP:UniProtKB. GO:004441 |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr50231 |
PHOSPHORYLATION |
157 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
256 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
234 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
252 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
258 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
222 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
233 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
165 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
163 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
255 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
250 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
253 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
249 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
152 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
244 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
246 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
152 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
157 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
165 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
222 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
224 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
233 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
234 |
T |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
253 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr50231 |
PHOSPHORYLATION |
258 |
S |
PhosphoSitePlus |
LTP |
N |
|
