HuLPr50234

Uniprot ID

PLPL3_HUMAN

Uniprot Acc

Q9NST1;B0QYI0;B2RCL3;B3KW00;Q6P1A1;Q96CB4;

Protein name

Patatin-like phospholipase domain-containing protein 3

Comment

FUNCTION: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities.||CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.||PATHWAY: Glycerolipid metabolism; triacylglycerol degradation.||SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.||ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NST1-1; Sequence=Displayed; Name=2; IsoId=Q9NST1-2; Sequence=VSP 036222; Note=No experimental confirmation available;||INDUCTION: By changes in energy balance: down-regulated following very low-calorie diet, whereas refeeding elevates the mRNA level.||POLYMORPHISM: Polymorphic variation at position 148 influences insulin secretion levels and obesity. In obese subjects the body mass index and waist are higher in carriers of the Ile-148 allele. The Ile-148 carriers also display decreased insulin secretion in response to oral glucose tolerance test. Met-148 allele carriers

Subcellular localization

Membrane; Single-pass type II membrane protein.

Gene name

patatin-like phospholipase domain containing 3

Protein sequence

MYDAERGWSLSFAGCGFLGFYHVGATRCLSEHAPHLLRDA RMLFGASAGALHCVGVLSGIPLEQTLQVLSDLVRKARSR NIGIFHPSFNLSKFLRQGLCKCLPANVHQLISGKIGISL TRVSDGENVLVSDFRSKDEVVDALVCSCFIPFYSGLIPP SFRGVRYVDGGVSDNVPFIDAKTTITVSPFYGEYDICPK VKSTNFLHVDITKLSLRLCTGNLYLLSRAFVPPDLKVLG EICLRGYLDAFRFLEEKGICNRPQPGLKSSSEGMDPEVA MPSWANMSLDSSPESAALAVRLEGDELLDHLRLSILPWD ESILDTLSPRLATALSEEMKDKGGYMSKICNLLPIRIMS YVMLPCTLPVESAIAIVQRLVTWLPDMPDDVLWLQWVTS QVFTRVLMCLLPASRSQMPVSSQQASPCTPEQDWPCWTP CSPKGCPAETKAEATPRSILRSSLNFFLGNKVPAGAEGL STFPSFSLEKSL

Database cross reference

RefSeq Protein accession:NP_079501
RefSeq Protein gi:17196626

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.

GO-F

GO:0051265; F:diolein transacylation activity; IDA:UniProtKB. GO:0051264; F:mono-olein transacylation activity; IDA:UniProtKB. GO:0004623; F:phospholipase A2 activity; IDA:UniProtKB. GO:0004806; F:triglyceride lipase activity; IDA:UniProtKB.

GO-P

GO:0019432; P:triglyceride biosynthetic process; IDA:UniProtKB. GO:0019433; P:triglyceride catabolic process; IDA:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr50234

PHOSPHORYLATION

211

S

PhosphoSitePlus

13310536

LTP

N